![]() Jakarta: Departemen Farmakologi dan Terapeutik Fakultas Kedokteran Universitas Indonesia 2012. Conclusion: Honey provides a protective effect on rat’s duodenal tissue given aspirin exposure.ġ.Ĝorwin, Elizabeth J. Results: Lighter damage was obtained in the treatment group (KP1 and KP2) compared to the negative control group (K-) (p <0.050). Data analysis used SPSS version 23.0 with Kruskal Wallis followed by Post Hoc Mann Whitney. The rats were killed on the 8th day and the duodenal was taken for histopathology assessment. One hour after administration of honey, rats were given aspirin 400 mg / kgBB. This study used 30 rats divided into 5 groups: normal control group (KN), treatment group M dose I (KP1) (1.55ml / kgBB),treatment group M dose II (KP2) (3.1 ml / kgBB), positive control group (K+) (sucralfate 4 ml / kgBB), and the negative control group (K-) (aspirin 400mg/kgBB). Methods : The design of this study was a randomized post test only control group. Objective/aim : Determine the protective effect of honey on aspirin induced duodenal tissue of wistar rats. Noor et al proved that honey can protect the body from the chemical toxic effects. Honey has antioxidant activity from (the) compounds contained in honey in the form of flavonoids and phenolic acids. Aspirin is one of group called NSAIDs which cause peptic ulcer disease. Background : Peptic ulcer is a damage to the mucosal layer generally in the stomach or duodenum. ![]()
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